泰国东北部人群中HLA - A和B抗原的分布。

Distribution of HLA-A and B antigens in northeastern-Thais.

作者信息

Romphruk A, Burusrux S, Puapairoj C, Urwijitaroon Y, Romphruk A, Leelayuwat C

机构信息

Blood Transfusion Centre, Faculty of Medicine, Khon Kaen University, Thailand.

出版信息

J Med Assoc Thai. 1996 Nov;79(11):732-6.

PMID:8997013

Abstract

The phenotype and gene frequencies of HLA class I were studied in the Northeastern Thai population. Blood samples were collected from 100 unrelated healthy Northeastern Thais. HLA-A and B antigens were typed by using the standard microlymphocytotoxicity test. Twelve HLA-A and twenty-five HLA-B antigens were found in this population. HLA-A2, A24, A11 and the HLA-B46, B15, B22 antigens are commonly found in this group. Linkage disequilibrium analysis indicated the existence of fifteen haplotypes. The HLA-A2, B46 haplotype was the most common. These results will be useful for further studies in anthropology, organ transplantation and MHC associated disease in Northeastern Thais.

摘要

对泰国东北部人群的HLA I类分子的表型和基因频率进行了研究。从100名无亲缘关系的健康泰国东北部人采集血样。采用标准微量淋巴细胞毒试验对HLA - A和B抗原进行分型。在该人群中发现了12种HLA - A抗原和25种HLA - B抗原。HLA - A2、A24、A11以及HLA - B46、B15、B22抗原在该组中较为常见。连锁不平衡分析表明存在15种单倍型。HLA - A2、B46单倍型最为常见。这些结果将有助于对泰国东北部人群在人类学、器官移植和MHC相关疾病方面的进一步研究。