泰国北部人群的人类白细胞抗原（HLA）基因频率

HLA gene frequencies of northern Thais.

作者信息

Fongsatikul L, Nantachit N, Kamtorn N, Leetrakool N

机构信息

Blood Bank Section, Chiang Mai University, Thailand.

出版信息

J Med Assoc Thai. 1997 Sep;80 Suppl 1:S38-42.

PMID:9347644

Abstract

We investigated the distribution of HLA-A and B locus, gene frequency (GF), antigen frequency (AF), haplotype frequency (HF) and non detectable antigens in Northern Thais. Of 289 native northern Thai people residing in Chiang Mai province for many generations were tested using lymphocytotoxicity test and 146 unrelated subjects were selected for analysis. The common alleles were A2, A11 and A24 for A locus with GF of 36.4%, 35.4% and 15.6%, respectively and B46, B40 and B13 for B locus with GF of 21.1%, 15.7% and 8.6%, respectively. The frequent linkage disequilibrium haplotypes were A2,B46; A33,B17 with HF of 15.9%; 5.0% and LD of 8.3%; 4.6%, respectively (p < 0.0001). The undetectable antigens (blanks) occurred with GF = 11.64% at A locus and GF = 4.92% at B locus. Comparing the GFs to other Thai ethnic groups, showed that the Northern Thais shared several alleles such as A2, A11, B46, and B62 in common with Dai Lue (Thai-speaking people who lived in the southern part of China), (p > 0.05), more than Thais, Thai/Chinese or present-day Thais (p < 0.001). Especially, HLA-B46 with the GF of 21.1% is considered to be a very typical antigen for Southern Mongoloids. These similarities will support the root of migration and origin of Northern Thais.

摘要

我们研究了泰国北部人群中HLA - A和B位点的分布、基因频率（GF）、抗原频率（AF）、单倍型频率（HF）以及不可检测抗原的情况。对居住在清迈省多代的289名泰国北部原住民进行了淋巴细胞毒性试验检测，并选取146名无关个体进行分析。A位点的常见等位基因是A2、A11和A24，基因频率分别为36.4%、35.4%和15.6%；B位点的常见等位基因是B46、B40和B13，基因频率分别为21.1%、15.7%和8.6%。常见的连锁不平衡单倍型是A2,B46；A33,B17，单倍型频率分别为15.9%；5.0%，连锁不平衡分别为8.3%；4.6%（p < 0.0001）。不可检测抗原（空白）在A位点的基因频率为11.64%，在B位点的基因频率为4.92%。将这些基因频率与其他泰国族群进行比较，结果显示泰国北部人群与傣泐（居住在中国南部的讲泰语人群）共享多个等位基因，如A2、A11、B46和B62（p > 0.05），比泰国人、泰裔华人或现代泰国人共享的更多（p < 0.001）。特别是，基因频率为21.1%的HLA - B46被认为是南方蒙古人种的一个非常典型的抗原。这些相似性将支持泰国北部人群的迁徙根源和起源。