[一例雷氏综合征尸检病例]

[An autopsy case of the Reye's syndrome].

作者信息

Kubo S, Orihara Y, Tsuda R, Hirose W, Matsumoto H, Kita T, Tanaka N, Nakasono I

机构信息

Department of Legal Medicine, Nagasaki University School of Medicine, Japan.

出版信息

Nihon Hoigaku Zasshi. 1996 Dec;50(6):416-21.

PMID:8997087

Abstract

A case of sudden unexpected natural death in a 6-year-old girl was reported. She was found in dead with vomiting on her bed in the morning on 24. December. Autopsy did not reveal any injuries and abnormalities on her appearance. Small amount of light yellowish mucus in her nose, trachea and bronchus was found. Brain was slightly edematous (1395 g in weight). Liver was 750 g in weight and focal yellowish lesions were observed on its cut surfaces. Microscopically fatty degeneration (granulous fatty deposits) was observed in hepatocytes. Immunohistochemical staining of mitochondria in heart showed no staining microscopically, and degeneration and breakdown of mitochondria were found electromicroscopically. From the results of autopsy and histopathological findings, her cause of death was diagnosed as the Reye's syndrome.

摘要

报告了一例6岁女孩突然意外自然死亡的病例。12月24日早晨，她被发现死在床上，伴有呕吐。尸检未发现其体表有任何损伤和异常。在她的鼻子、气管和支气管中发现少量淡黄色黏液。大脑轻度水肿（重量为1395克）。肝脏重量为750克，在其切面上观察到局灶性淡黄色病变。显微镜下观察到肝细胞有脂肪变性（颗粒状脂肪沉积）。心脏线粒体的免疫组织化学染色在显微镜下未显示染色，电镜下发现线粒体有变性和破坏。根据尸检结果和组织病理学发现，她的死因被诊断为瑞氏综合征。