Svoboda D J, Reddy J K
Lab Invest. 1975 May;32(5):571-9.
A study of six patients with Reye's syndrome indicated that, by light microscopy, inflammation and necrosis of liver cells are especially prominent in fatal cases. Contrary to previous reports, electron microscopic examination indicated that, aside from loss of matrix dense granules, alterations in mitochondrial structure were minimal or absent. Although an increase in the number of liver cell microbodies has been reported, no such increase was apparent in the present study. The most unusual ultrastructural change in microbodies in the present study was the appearance of noncrystalline cores in the matrix. No ultrastructural features served to distinguish patients who died from those who survived. Although derangement of mitochondrial function may be important in the pathogenesis of Reye's syndrome, such derangement is not necessary reflected in the ultrastructure of mitochondria.
一项针对6例瑞氏综合征患者的研究表明，通过光学显微镜观察，在致命病例中肝细胞的炎症和坏死尤为明显。与之前的报道相反，电子显微镜检查显示，除了基质致密颗粒的丢失外，线粒体结构的改变微乎其微或不存在。尽管有报道称肝细胞微体数量增加，但在本研究中并未观察到这种增加。本研究中微体最不寻常的超微结构变化是基质中出现非晶状核心。没有超微结构特征可用于区分死亡患者和存活患者。尽管线粒体功能紊乱可能在瑞氏综合征的发病机制中起重要作用，但这种紊乱并不一定会在线粒体的超微结构中体现出来。
