Lundgren T, Twetman S, Johansson I, Crossner C G, Birkhed D
Department of Dentistry, King Faisal Specialist Hospital and Research Centre, Riyadh, Kingdom of Saudi Arabia.
J Clin Periodontol. 1996 Dec;23(12):1068-72. doi: 10.1111/j.1600-051x.1996.tb01805.x.
The aim of the present study was to evaluate the salivary secretion rate and composition in a group of 16 children and young adults (6-27 years) with Papillon-Lefèvre Syndrome (PLS), and to compare the findings with a group (n = 16) of healthy controls. Unstimulated and stimulated whole saliva was collected at least 2 h after meals and the secretion rate determined. The stimulated saliva was assessed for buffer capacity, total protein, peroxidase and hexosamine, while the unstimulated samples were evaluated for total protein, lysozyme, thiocyanate, lactoferrin and salivary IgA. Both the unstimulated (p < 0.01) and stimulated (p < 0.05) saliva secretion rates were significantly lower among the PLS patients compared with the controls. Furthermore salivary buffer capacity was significantly (p < 0.01) lower in the PLS patients. The total protein content in saliva was comparatively high in the study group, while the concentrations of immunoglobulins and non-immunoglobulins were within normal ranges. When calculating the output of the assessed antimicrobial factors, the mean peroxidase level in stimulated whole saliva was found to be significantly (p < 0.01) lower in the PLS patients than in the healthy controls. In conclusion, the present study indicates an impaired water secretion and a somewhat altered saliva gland function in children and young adults with PLS.
本研究的目的是评估一组16名患有帕皮永-勒费夫尔综合征（PLS）的儿童和青年（6至27岁）的唾液分泌率和成分，并将结果与一组16名健康对照者进行比较。餐后至少2小时收集非刺激性和刺激性全唾液，并测定分泌率。对刺激性唾液进行缓冲能力、总蛋白、过氧化物酶和氨基己糖评估，而对非刺激性样本进行总蛋白、溶菌酶、硫氰酸盐、乳铁蛋白和唾液免疫球蛋白A评估。与对照组相比，PLS患者的非刺激性（p<0.01）和刺激性（p<0.05）唾液分泌率均显著降低。此外，PLS患者的唾液缓冲能力显著降低（p<0.01）。研究组唾液中的总蛋白含量相对较高，而免疫球蛋白和非免疫球蛋白的浓度在正常范围内。在计算所评估的抗菌因子的产量时，发现PLS患者刺激性全唾液中的平均过氧化物酶水平显著低于健康对照组（p<0.01）。总之，本研究表明，患有PLS的儿童和青年存在水分泌受损和唾液腺功能略有改变的情况。
