Firatli E, Gürel N, Efeoğlu A, Cebeci I
Department of Periodontology, School of Dentistry, University of Istanbul, Turkey.
J Clin Periodontol. 1996 Dec;23(12):1104-11. doi: 10.1111/j.1600-051x.1996.tb01811.x.
The clinical and immunological data from 4 patients with generalized prepubertal periodontitis are presented. The peripheral blood neutrophil chemotaxis was measured using zymosan activated sera as the chemoattractant. All of the 4 patients have shown depressed neutrophil chemotaxis compared to those of the healthy controls. Peripheral blood lymphocyte subpopulations were analysed by double-coloured flow cytometry using monoclonal antibodies for the receptors CD2, CD3, CD4, CD8, CD19, CD29, CD45RA+, 34,29dK, CD56. CD11b/CD18. Lymphocytes bearing CD3 receptors showed a significant decrease compared to those of the controls. Natural killer cells were lowered in 3 of the 4 cases. All of the patients showed a higher increase in CD11b/CD18 expression. The evaluation of CD11b/CD18 receptor in peripheral blood leukocytes may be of help explaining the rôle of neutrophils in the pathogenesis of the disease.
本文呈现了4例青春期前广泛性牙周炎患者的临床和免疫学数据。使用酵母聚糖激活血清作为趋化剂来测量外周血中性粒细胞趋化性。与健康对照组相比，所有4例患者均表现出中性粒细胞趋化性降低。使用针对受体CD2、CD3、CD4、CD8、CD19、CD29、CD45RA+、34、29dK、CD56、CD11b/CD18的单克隆抗体，通过双色流式细胞术分析外周血淋巴细胞亚群。与对照组相比，带有CD3受体的淋巴细胞显著减少。4例中有3例自然杀伤细胞减少。所有患者的CD11b/CD18表达均有较高程度的增加。对外周血白细胞中CD11b/CD18受体的评估可能有助于解释中性粒细胞在该疾病发病机制中的作用。
