Egwunyenga O A, Ajayi J A, Popova-Duhlinska D D, Nmorsi O P
Department of Zoology, University of Jos, Nigeria.
Cent Afr J Med. 1996 Sep;42(9):265-8.
To establish the prevalence of cord malaria parasitaemia in Nigerians and to elucidate its effect on birthweight.
Case series.
1,905 women resident in three parts of Nigeria.
University of Jos Teaching Hospital, Jos, Plateau State, Bauchi Specialist Hospital and Eku Baptist Hospital, Eku Delta State.
21.6 pc (405) were infected with Plasmodium falciparum. The prevalences by residence were 21.8 pc in Bauchi, 23.2 pc in Jos and 17.5 pc in Eku. The cord malaria prevalence was significantly higher among newborns of first pregnancies than those of two or more pregnancies. Although no significant seasonal fluctuation in mean birthweights was found, the mean for the August to October quarter were the lowest in the three study sites. The mean birthweights of newborns with parasitized cords were generally lower than those that were not parasitized. Birthweights of infected cords also decreased with increasing parasite densities. Of the newborns 215 (11.2 pc) weighed < or = 500 g, of which 202 (10.5 pc) had cord malaria.
There is a need for more efficient malaria chemoprophylaxis regime during antenatal care in public hospitals to effectively manage malaria in pregnancy and reduce the incidence of low birthweight.
确定尼日利亚人脐带血疟原虫血症的患病率，并阐明其对出生体重的影响。
病例系列研究。
居住在尼日利亚三个地区的1905名妇女。
乔斯大学教学医院（位于高原州乔斯）、包奇专科医院以及三角州埃库浸礼会医院。
21.6%（405例）感染恶性疟原虫。按居住地划分的患病率分别为：包奇21.8%、乔斯23.2%、埃库17.5%。初产妇新生儿的脐带血疟疾患病率显著高于经产妇新生儿。尽管未发现平均出生体重有明显的季节性波动，但在三个研究地点，8月至10月这一季度的平均出生体重最低。脐带血有疟原虫寄生的新生儿平均出生体重普遍低于未寄生的新生儿。感染脐带血的新生儿出生体重也随着寄生虫密度的增加而降低。215名（11.2%）新生儿体重≤500克，其中202名（10.5%）有脐带血疟疾。
公立医院产前护理期间需要更有效的疟疾化学预防方案，以有效管理妊娠期疟疾并降低低出生体重的发生率。
