Egwunyenga O A, Ajayi J A, Duhlinska-Popova D D
Department of Zoology, Faculty of Science, University of Jos, Nigeria.
J Commun Dis. 1995 Jun;27(2):77-83.
The findings of a prospective study of 656 near-term pregnant women, and of the cord and peripheral blood of newborns of positive mothers are reported. 292 (44.51%) of the pregnant women were infected with P. falciparum. Further microscopic screening of the cord blood of newborns of the 292 positive cases at delivery showed a parasite rate of 10.95%. Transplacental passage of P. falciparum was confirmed by detection of parasitemia in the peripheral blood of 2.82% of newborns within 7 days of birth. Serological investigation of sera of 284 newborns by Indirect Fluorescent Technique (IFA) with P. falciparum IgM specific conjugate indicated that 72 (25.35%) had IgM antibodies of P. falciparum in their blood. The average birth weight of seropositive newborns was 400 gm less than seronegative ones. There was no significant difference in the rate of neonatal infection regardless of whether or not the mothers had taken chloroquine prophylaxis.
报告了一项对656名近期孕妇以及阳性母亲所生新生儿的脐带血和外周血进行的前瞻性研究结果。292名（44.51%）孕妇感染了恶性疟原虫。对这292例阳性病例的新生儿脐带血在分娩时进行进一步显微镜筛查，结果显示寄生虫感染率为10.95%。通过检测出生7天内2.82%新生儿外周血中的疟原虫血症，证实了恶性疟原虫的胎盘传播。采用针对恶性疟原虫IgM的特异性结合物，通过间接荧光技术（IFA）对284名新生儿的血清进行血清学调查，结果表明72名（25.35%）新生儿血液中存在恶性疟原虫IgM抗体。血清反应阳性新生儿的平均出生体重比血清反应阴性新生儿轻400克。无论母亲是否接受过氯喹预防，新生儿感染率均无显著差异。
