细胞存活与增殖。对信号的首要需求：从单细胞系统到多细胞系统。

Cell survival and multiplication. The overriding need for signals: from unicellular to multicellular systems.

作者信息

Rasmussen L, Christensen S T, Schousboe P, Wheatley D N

机构信息

Department of Anatomy and Cell Biology, Odense University, Denmark.

出版信息

FEMS Microbiol Lett. 1996 Apr 1;137(2-3):123-8. doi: 10.1016/0378-1097(96)00053-5.

DOI:10.1016/0378-1097(96)00053-5

PMID:8998973

Abstract

There are clear similarities in the control mechanisms for cell survival and multiplication in the two eukaryotes, the ciliate Tetrahymena thermophila and the yeast, Saccharomyces cerevisiae. Cell multiplication in both organisms is activated by the same compounds (phorbol esters, diacylglycerol, tetrapyrroles, etc.). These compounds also affect cell multiplication and other activities in mammalian cell systems. This homology in control mechanisms in two distinct groups of unicellular eukaryotes on the one hand, and in cells from multicellular animals on the other, leads us to propose that these cytoplasmic control mechanisms for cell survival and multiplication originated in the unicellular eukaryotes.

摘要

在两种真核生物——嗜热四膜虫和酿酒酵母中，细胞存活与增殖的控制机制存在明显相似之处。这两种生物体中的细胞增殖均由相同的化合物（佛波酯、二酰基甘油、四吡咯等）激活。这些化合物也会影响哺乳动物细胞系统中的细胞增殖及其他活动。一方面，这两类不同的单细胞真核生物在控制机制上具有同源性；另一方面，它们与多细胞动物的细胞也存在同源性。这使我们提出，这些细胞存活与增殖的细胞质控制机制起源于单细胞真核生物。