[致癌性马立克氏病病毒（MDV）JM株A和B抗原糖蛋白编码基因的克隆与测序]
[Cloning and sequencing of genes coding the glycoproteins of antigens A and B of oncogenic strain JM of Marek disease virus (MDV)].
作者信息
Bedristov A I, Bakhtina M M, Krendel'shchikov A V, Babkin I V, Ivan'kina T Iu, Susloparov M A
出版信息
Mol Gen Mikrobiol Virusol. 1996 Jul-Sep(3):6-11.
The genes encoding the precursors of secretory glycoprotein gp57-65 (A antigen) and glycoprotein complex gp100, gp60, gp48 (B antigen) of virulent strain JM of Marek's disease virus (MDV) have been cloned using PCR of viral DNA. Nucleotide sequences of both genes have been determined and amino acid sequence of the precursor peptides predicted, and compared with the corresponding sequences of other MDV strains. The results will be used for developing methods for the diagnosis of Marek's disease and vaccination against it.
利用马立克氏病病毒（MDV）强毒株JM的病毒DNA进行聚合酶链反应（PCR），克隆了编码分泌性糖蛋白gp57 - 65（A抗原）前体和糖蛋白复合物gp100、gp60、gp48（B抗原）的基因。已确定了这两个基因的核苷酸序列，并预测了前体肽的氨基酸序列，还与其他MDV毒株的相应序列进行了比较。这些结果将用于开发马立克氏病的诊断方法和针对该病的疫苗接种方法。
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