东京葛藤素：一种从东京紫玉盘分离得到的新型番荔枝内酯

Tonkinelin: a novel annonaceous acetogenin from Uvaria tonkinensis.

作者信息

Chen Y, Yu D Q

机构信息

Institute of Materia Medica, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, People's Republic of China.

出版信息

Planta Med. 1996 Dec;62(6):512-4. doi: 10.1055/s-2006-957959.

DOI:10.1055/s-2006-957959

PMID:9000883

Abstract

Further studies on the root bark of Uvaria tonkinensis Finet et Gagnep. (Annonacease) led to the isolation of a new Annonaceous acetogenin, tonkinelin (1). The structure of 1 was elucidated on the basis of spectral data and chemical evidence. This compound represents an unusual type of C37 Annonaceous acetogenin, having neither tetrahydrofuran (THF) nor epoxide rings and possessing only a vicinal diol in the hydrocarbon chain. Preliminary pharmacological tests showed that tonkinelin (1) inhibits human leukemia (HL-60) and human colon adenocarcinoma (HCT-8) cell lines in vitro.

摘要

对东京紫玉盘（番荔枝科）根皮的进一步研究导致分离出一种新的番荔枝乙酰精，东京紫玉盘素（1）。根据光谱数据和化学证据阐明了1的结构。该化合物代表一种不寻常类型的C37番荔枝乙酰精，既没有四氢呋喃（THF）环也没有环氧环，并且在烃链中仅具有邻二醇。初步药理试验表明，东京紫玉盘素（1）在体外抑制人白血病（HL - 60）和人结肠腺癌（HCT - 8）细胞系。