Lee I H, Zhao C, Cho Y, Harwig S S, Cooper E L, Lehrer R I
Section of Molecular Host Defense, Department of Medicine, UCLA School of Medicine, Los Angeles, CA 90095-1690, USA.
FEBS Lett. 1997 Jan 3;400(2):158-62. doi: 10.1016/s0014-5793(96)01374-9.
Hemocytes from the invertebrate Styela clava, a solitary tunicate, contained a family of four alpha-helical antimicrobial peptides that were purified, sequenced and named clavanins A, B, C and D. Each clavanin contained 23 amino acid residues and was C-terminally amidated. The tunicate peptides resembled magainins in size, primary sequence and antibacterial activity. Synthetic clavanin A was prepared and displayed comparable antimicrobial activity to magainins and cecropins. The presence of alpha-helical antimicrobial peptides in the hemocytes of a urochordate suggests that such peptides are primeval effectors of innate immunity in the vertebrate lineage.
来自无脊椎动物柄海鞘（一种独居被囊动物）的血细胞含有一族由四个α-螺旋抗菌肽组成的物质，这些抗菌肽经过纯化、测序后被命名为海鞘素A、B、C和D。每种海鞘素含有23个氨基酸残基，且C端为酰胺化形式。被囊动物肽在大小、一级序列和抗菌活性方面与蛙皮素相似。合成的海鞘素A已制备出来，其抗菌活性与蛙皮素和天蚕素相当。在一种尾索动物的血细胞中存在α-螺旋抗菌肽，这表明此类肽是脊椎动物谱系中固有免疫的原始效应物。
