一种广泛表达的非典型钠通道的结构与分布
Structure and distribution of a broadly expressed atypical sodium channel.
作者信息
Akopian A N, Souslova V, Sivilotti L, Wood J N
机构信息
Department of Anatomy and Developmental Biology, University College, London, UK.
出版信息
FEBS Lett. 1997 Jan 3;400(2):183-7. doi: 10.1016/s0014-5793(96)01389-0.
A cDNA clone isolated from a rat dorsal root ganglion library encodes a 195 kDa voltage-gated sodium channel-like protein (SCL-11) with homology to the mouse (87%) and human (72%) atypical Na+ channels and rat partial clone NaG (98%). Two dominant mRNAs of 4.5 and 7 kb are expressed. The transcripts are present in lung, Schwann cells, pituitary and tissues containing smooth muscle cells. No functional channels could be detected on oocyte injection with cRNA, consistent with the absence of structural features necessary for voltage-gated sodium channel activity.
从大鼠背根神经节文库中分离出的一个cDNA克隆编码一种195 kDa的电压门控钠通道样蛋白（SCL-11），它与小鼠非典型Na⁺通道（87%同源性）、人类非典型Na⁺通道（72%同源性）以及大鼠部分克隆NaG（98%同源性）具有同源性。表达出两种主要的mRNA，大小分别为4.5 kb和7 kb。这些转录本存在于肺、施万细胞、垂体以及含有平滑肌细胞的组织中。向卵母细胞注射cRNA后未检测到功能性通道，这与缺乏电压门控钠通道活性所需的结构特征一致。
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