Irvine R J, White J M, Head R J
Department of Clinical and Experimental Pharmacology, University of Adelaide, South Australia.
Life Sci. 1995 Feb 17;56(13):1073-8. doi: 10.1016/0024-3205(95)00043-6.
This study investigated the effects of captopril, hydralazine and losartan on the locomotor activity, tailflick and hot plate latencies in spontaneously hypertensive rats (SHR) and their genetic controls the Wistar-Kyoto rat (WKY). The increased hot plate latencies normally exhibited by the spontaneously hypertensive rat were reduced or abolished by captopril (95 mg/kg/day p.o.) and losartan (18 mg/kg/day p.o.) treatment, but were unaffected by hydralazine (19 mg/kg/day p.o.). There were no observable effects of any of the drugs on tailflick latencies or locomotor activity. The results highlight a potential role for angiotensin II in analgesia that is independent of blood pressure change.
本研究调查了卡托普利、肼屈嗪和氯沙坦对自发性高血压大鼠（SHR）及其基因对照品系Wistar-Kyoto大鼠（WKY）的运动活性、甩尾和热板潜伏期的影响。自发性高血压大鼠通常表现出的热板潜伏期增加，经卡托普利（口服95mg/kg/天）和氯沙坦（口服18mg/kg/天）治疗后缩短或消除，但不受肼屈嗪（口服19mg/kg/天）影响。这些药物对甩尾潜伏期或运动活性均无明显影响。结果突出了血管紧张素II在镇痛中不依赖于血压变化的潜在作用。
