Melmed S, Lewin L M, Bank H
Am J Med Sci. 1977 Jul-Aug;274(1):55-9. doi: 10.1097/00000441-197707000-00007.
In order to determine the mechanism of elevated serum inositol in renal failure, the clearance values of inositol and of creatinine were measured in patients with normal kidney function and in those whose renal function was impaired due to varying causes. Mean serum inositol level in controls was 5.6 microgram/ml, and in patients with renal failure 28.6 microgram/ml. In control patients, inositol clearance was 2.8 ml/min, and tubular reabsorption of inositol was found to be over 97 percent. The inositol clearance of patients in renal failure varied from 0.62 to 17 ml/min. The ratio inositol clearance/creatinine clearance was elevated in uremic patients. Total amounts of inositol excreted in the urine of uremic patients were consistently higher than those excreted by control patients. The elevated serum inositol levels seen in renal failure were therefore not primarily caused by inability of the diseased kidney to excrete inositol.
为了确定肾衰竭时血清肌醇升高的机制，对肾功能正常的患者以及因各种原因导致肾功能受损的患者测定了肌醇和肌酐的清除率。对照组患者的平均血清肌醇水平为5.6微克/毫升，肾衰竭患者为28.6微克/毫升。在对照患者中，肌醇清除率为2.8毫升/分钟，发现肌醇的肾小管重吸收率超过97%。肾衰竭患者的肌醇清除率在0.62至17毫升/分钟之间变化。尿毒症患者的肌醇清除率/肌酐清除率比值升高。尿毒症患者尿液中排出的肌醇总量始终高于对照患者。因此，肾衰竭时出现的血清肌醇水平升高并非主要由患病肾脏排泄肌醇的能力不足所致。
