Pitkänen E
Clin Chim Acta. 1976 Sep 20;71(3):461-8. doi: 10.1016/0009-8981(76)90097-8.
Serum and urinary myo-inositol and urinary glucose were estimated by means of gas-liquid chromatography in 54 patients with glomerulonephritis with and without renal failure. myo-Inositol clearance was calculated and an index was formulated which reflected changes in glomerular filtration, tubular reabsorption and catabolism of myo-inositol by the kidney. Serum and urinary myo-inositol levels were increased in glomerulonephritis with a close correlation to the degree of renal failure. In advanced forms of glomerulonephritis, glomerular filtration, tubular reabsorption and catabolism of myo-inositol were shown to be markedly deranged. Evidence obtained showed further that a derangement of tubular reabsorption and catabolism of myo-inositol also accompany milder forms of glomerulonephritis without decreased glomerular filtration. The myo-inositol index value, especially, was increased in patients with signs of disease activity as indicated by a histological examination of the kidney tissue. The index can also be regarded as a highly sensitive test of renal failure. Low grade glucosuria was shown to be frequently associated with glomerulonephritis with renal failure. Evidence was produced which suggested that the tubular reabsorption of myo-inositol was deranged earlier than glucose reabsorption in glomerulonephritis, although they may share a common step in the reabsorption process. The data suggest that the estimation of serum and urinary myo-inositol has advantages in the evaluation of kidney function.
采用气液色谱法对54例伴有或不伴有肾衰竭的肾小球肾炎患者的血清和尿液中的肌醇以及尿液中的葡萄糖进行了测定。计算了肌醇清除率，并制定了一个指数，该指数反映了肾脏对肌醇的肾小球滤过、肾小管重吸收和分解代谢的变化。肾小球肾炎患者的血清和尿液肌醇水平升高，且与肾衰竭程度密切相关。在晚期肾小球肾炎中，肌醇的肾小球滤过、肾小管重吸收和分解代谢明显紊乱。进一步获得的证据表明，在肾小球滤过率未降低的较轻形式的肾小球肾炎中，肌醇的肾小管重吸收和分解代谢也会紊乱。尤其是，根据肾组织的组织学检查显示，有疾病活动迹象的患者的肌醇指数值会升高。该指数也可被视为肾衰竭的一项高度敏感检测指标。轻度糖尿被证明经常与伴有肾衰竭的肾小球肾炎相关。有证据表明，在肾小球肾炎中，肌醇的肾小管重吸收比葡萄糖重吸收更早出现紊乱，尽管它们在重吸收过程中可能有一个共同步骤。数据表明，血清和尿液肌醇的测定在评估肾功能方面具有优势。
