Lindhagen T
Dept of Surgery, University Hospital MAS, Malmö, Sweden.
Eur J Surg. 1996 Dec;162(12):969-72.
To assess whether it is the steroid alone or the gentle physical retraction combined with ointment that is responsible for the excellent results observed with topical steroid treatment of unretractable foreskin.
Prospective, randomised, double-blind study.
University hospital, Sweden.
30 Boys randomised to be treated with clobetasol propionate (n = 15) or placebo (n = 15).
The boys were examined 1, 2 and 6 months, respectively, after treatment.
Comparison between the effects of clobetasol propionate and placebo.
Two patients in the steroid group and one in the placebo group withdrew from the study. 10 Boys in the steroid group showed an improvement within 2 months. The remaining 3 boys had no effect and were circumcised. Histopathological examination showed lichen sclerosus et atrophicus. Seven boys in the placebo group improved. The 7 non-responders were prescribed clobetasol propionate ointment, and all 7 improved.
17 of 27 boys referred with "phimosis" were successfully treated with an ointment and gentle traction. When clobetasol propionate was given the non-responders success rate was increased to 24/27 (89%).
评估对于不可回缩性包皮，究竟是单纯使用类固醇，还是轻柔的物理回缩联合药膏，导致了局部类固醇治疗所观察到的良好效果。
前瞻性、随机、双盲研究。
瑞典大学医院。
30名男孩，随机分为丙酸氯倍他索治疗组（n = 15）和安慰剂组（n = 15）。
治疗后分别在1个月、2个月和6个月对男孩进行检查。
比较丙酸氯倍他索和安慰剂的效果。
类固醇组有2名患者、安慰剂组有1名患者退出研究。类固醇组有10名男孩在2个月内病情改善。其余3名男孩无效并接受了包皮环切术。组织病理学检查显示为硬化性苔藓及萎缩。安慰剂组有7名男孩病情改善。对7名无反应者给予丙酸氯倍他索药膏，所有7名均有改善。
27名因“包茎”前来就诊的男孩中，17名通过药膏和轻柔牵引得到成功治疗。给予丙酸氯倍他索时，无反应者的成功率提高到24/27（89%）。
