Gupte M D, Vallishayee R S, Anantharaman D S, Britto R L, Nagaraju B
CJIL Field Unit (ICMR), Avadi, Madras.
Indian J Lepr. 1996 Oct-Dec;68(4):315-24.
M.w vaccine is one of the antileprosy vaccines under test in an ongoing comparative vaccine trial in South India. The objective of the present study was to examine the sensitizing ability, as measured by skin test reactions to Rees' MLSA and lepromin, and reactogenicity of M.w vaccine in the local population. Two doses of M.w, 1 x 10(9) bacilli and 5 x 10(9) bacilli, were used, in two separate studies of 395 and 400 "healthy" individuals aged 1-65 years. In each study, the study subjects received either M.w vaccine or normal saline (control), by random allocation. The results showed that healing of vaccination lesions was uneventful although the healing process was somewhat prolonged with the higher dose. The mean size of lesions was 7.0 mm and 9.5 mm with the low and high doses of the vaccine, respectively. The results also showed that M.w vaccine in a dose of 1 x 10(9) bacilli, failed to induce post-vaccination sensitization as measured by reactions to Rees' MLSA and by Fernandez and Mitsuda reactions to lepromin-A. However, when the dose of the vaccine was increased to 5 x 10(9) bacilli the mean sizes of post-vaccination reactions to Rees' MLSA and lepromin-A (both early and late) were significantly larger in the vaccine group compared to that in the control group. The sensitizing effect attributable to the vaccine was of the order of 1.5 mm to 1.8 mm.
M.w疫苗是正在印度南部进行的一项比较疫苗试验中接受测试的抗麻风病疫苗之一。本研究的目的是通过对里斯氏多菌型麻风菌素皮肤试验反应和麻风菌素反应来检测M.w疫苗在当地人群中的致敏能力和反应原性。在两项分别针对395名和400名年龄在1至65岁的“健康”个体的研究中，使用了两剂M.w疫苗，剂量分别为1×10⁹菌和5×10⁹菌。在每项研究中，研究对象通过随机分配接受M.w疫苗或生理盐水（对照）。结果表明，疫苗接种部位的愈合过程顺利，尽管高剂量组的愈合过程有所延长。低剂量和高剂量疫苗接种部位病变的平均大小分别为7.0毫米和9.5毫米。结果还表明，以里斯氏多菌型麻风菌素反应以及对麻风菌素A的费尔南德斯反应和光田反应来衡量，1×10⁹菌剂量的M.w疫苗未能诱导接种后致敏。然而，当疫苗剂量增加到5×10⁹菌时，与对照组相比，疫苗组接种后对里斯氏多菌型麻风菌素和麻风菌素A（早期和晚期）反应的平均大小显著更大。疫苗引起的致敏效应约为1.5毫米至1.8毫米。
