Sethi N C, Madadi A J, Bhandari S
Dept. of Dermatology, MGM Medical College, Indore.
Indian J Lepr. 1996 Oct-Dec;68(4):325-33.
Serum zinc, copper, magnesium, total proteins and albumin-globulin fractions and superoxide dismutase (SOD) were estimated in 80 untreated patients with TT/BT/BL/LL type of leprosy and in 40 controls. The investigations were repeated on day 30, 60 and 120 after starting multidrug therapy (MDT-WHO) on the patients. Serum zinc was significantly lowered in all types of leprosy on days 0 and 30. Serum copper was significantly raised in all types of leprosy. This was not significant in BT/TT cases on 60, 120 days. There was a correlation between serum zinc and copper levels and the severity and type of leprosy. The lowering of serum magnesium values were not significant. With therapy, there was a shift of all the three elements towards normal values. Serum total proteins reduction was not significant. Serum albumin was significantly lowered in all types of leprosy. Serum globulin was significantly raised in all types of leprosy. This rise in TT/BT was not significant on day 60 and 120 after starting treatment. Serum SOD was significantly reduced in all the untreated cases. It gradually increased with the clinical improvement under MDT.
对80例未经治疗的TT/BT/BL/LL型麻风患者和40名对照者的血清锌、铜、镁、总蛋白、白蛋白 - 球蛋白组分及超氧化物歧化酶（SOD）进行了测定。在患者开始多药联合治疗（世界卫生组织多药联合化疗方案，MDT - WHO）后的第30、60和120天重复进行这些检查。在第0天和第30天，所有类型麻风患者的血清锌均显著降低。所有类型麻风患者的血清铜均显著升高。在第60天和第120天，BT/TT型病例中这种升高不显著。血清锌和铜水平与麻风的严重程度和类型之间存在相关性。血清镁值降低不显著。随着治疗，所有这三种元素的值都向正常水平转变。血清总蛋白降低不显著。所有类型麻风患者的血清白蛋白均显著降低。所有类型麻风患者的血清球蛋白均显著升高。在开始治疗后的第60天和第120天，TT/BT型患者血清球蛋白的这种升高不显著。所有未经治疗的病例中血清SOD均显著降低。在多药联合化疗下，随着临床症状改善，血清SOD逐渐升高。
