嗜酸性粒细胞增多性肌痛和中毒性油综合征患者的抗磷脂抗体
Antiphospholipid antibodies in patients with eosinophilia myalgia and toxic oil syndrome.
作者信息
Carreira P E, Montalvo M G, Kaufman L D, Silver R M, Izquierdo M, Gomez-Reino J J
机构信息
Rheumatology Department, Hospital 12 de Octubre, Madrid, Spain.
出版信息
J Rheumatol. 1997 Jan;24(1):69-72.
OBJECTIVE
To explore whether antiphospholipid antibodies (aPL) are markers of vascular related damage or merely evidence of toxic related autoimmunity, we investigated the presence of different aPL in patients with toxic oil syndrome (TOS) and compared the profile with patients with eosinophilia myalgia syndrome (EMS).
METHODS
Reactivity against cardiolipin, P-serine, P-inositol, and P-choline was investigated by ELISA in the blood of 266 patients with acute and chronic TOS, 25 healthy relatives of TOS patients, and 48 patients with EMS.
RESULTS
32% of TOS and 13% of EMS patients had IgG antibodies against cardiolipin and other polyanions. 20% of both TOS and EMS patients presented IgM antibodies against anionic and zwitterionic phospholipids. 36% of TOS healthy relatives had IgM antibodies against differently charged phospholipids. Among 200 patients with chronic TOS, there was no significant association between antibodies and clinical manifestations.
CONCLUSION
aPL with different specificity are present in a high percentage of patients with TOS and EMS. The significance of these antibodies remains unclear.
目的
为了探究抗磷脂抗体（aPL）是血管相关损伤的标志物还是仅仅是毒性相关自身免疫的证据，我们调查了有毒油综合征（TOS）患者中不同aPL的存在情况，并将其特征与嗜酸性粒细胞性肌痛综合征（EMS）患者进行了比较。
方法
通过酶联免疫吸附测定法（ELISA）检测了266例急性和慢性TOS患者、25例TOS患者的健康亲属以及48例EMS患者血液中针对心磷脂、磷酸丝氨酸、磷酸肌醇和磷酸胆碱的反应性。
结果
32%的TOS患者和13%的EMS患者有抗心磷脂和其他多阴离子的IgG抗体。20%的TOS患者和EMS患者出现了抗阴离子和两性离子磷脂的IgM抗体。36%的TOS健康亲属有抗不同电荷磷脂的IgM抗体。在200例慢性TOS患者中，抗体与临床表现之间无显著关联。
结论
高比例的TOS和EMS患者存在具有不同特异性的aPL。这些抗体的意义仍不清楚。
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