Kopala L C, Lewine R, Good K P, Fluker M, Martzke J S, Lapointe J S, Honer W G
Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada.
J Psychiatry Neurosci. 1997 Jan;22(1):56-60.
Ample evidence supports sex differences in the clinical features of schizophrenia. In this regard, estrogen may contribute to later onset and less severe course of illness in women. Direct investigation of hormonal status in schizophrenia is extremely difficult. The present report documents the clinical features of schizophrenia in a young woman with long-standing hyperandrogenism related to polycystic ovarian disease. We postulate that hyperandrogenism contributed to a relatively early onset, olfactory dysfunction, and other clinical features of schizophrenia more commonly associated with men. Additionally, acute estrogen depletion following cessation of oral contraceptives may have precipitated psychosis, while recommencement of oral contraceptives could have contributed to subsequent improvement in symptoms.
大量证据支持精神分裂症临床特征存在性别差异。在这方面，雌激素可能导致女性发病较晚且病程较轻。直接研究精神分裂症患者的激素状态极其困难。本报告记录了一名患有与多囊卵巢疾病相关的长期高雄激素血症的年轻女性精神分裂症的临床特征。我们推测，高雄激素血症导致了相对较早的发病、嗅觉功能障碍以及其他更常见于男性的精神分裂症临床特征。此外，口服避孕药停药后雌激素急剧减少可能引发了精神病，而重新开始服用口服避孕药可能有助于随后症状的改善。
