Rethman J, Rethman M, Suzuki J
University of Pittsburgh, School of Dental Medicine, Pennsylvania, USA.
Pract Periodontics Aesthet Dent. 1995 Aug;7 Suppl:1-8.
Bacterial plaque contributes to the development and progression of periodontal diseases. Therefore, therapeutics designed to stop or slow periodontal destruction must limit or eliminate the deleterious effects of plaque. Despite the recognized beneficial effects of in-office surgical and nonsurgical periodontal therapies and home mechanical plaque control, antimicrobials have been used locally, systematically, or in combination to limit plaque activity. This article discusses a new, localized antimicrobial delivery method. The technique discussed employs an ethylene/vinyl acetate copolymer, containing tetracycline hydrochloride. Description of this polymeric fiber, indications for its use, placement technique, patient education, the role of auxiliaries, and practice management aspects are reviewed. The future potential of sustained-release local pharmaceutical devices is addressed.
细菌菌斑会导致牙周疾病的发生和发展。因此，旨在阻止或减缓牙周组织破坏的治疗方法必须限制或消除菌斑的有害影响。尽管人们已经认识到诊所内手术和非手术牙周治疗以及家庭机械性菌斑控制的有益效果，但抗菌药物仍被局部、全身或联合使用，以限制菌斑活性。本文讨论一种新的局部抗菌药物递送方法。所讨论的技术采用了一种含有盐酸四环素的乙烯/醋酸乙烯共聚物。本文对这种聚合物纤维进行了描述，介绍了其使用指征、放置技术、患者教育、辅助工具的作用以及实践管理方面的内容，并探讨了缓释局部给药装置的未来潜力。
