Jeunemaitre X, Ledru F, Battaglia S, Guillanneuf M T, Courbon D, Dumont C, Darmon O, Guize L, Guermonprez J L, Diebold B, Ducimetière P
Laboratoire de Biologie Moléculaire, Ilôt des Mariniers, Assistance Publique-Hôpitaux de Paris, Hôpital Broussais, France.
Hum Genet. 1997 Jan;99(1):66-73. doi: 10.1007/s004390050313.
Genetic polymorphisms of the renin-angiotensin system (RAS) have been associated with coronary artery disease (CAD) but no relation between these polymorphisms and coronary atherosclerosis has yet been systematically evaluated. The CORGENE study is a cross-sectional study involving 463 Caucasians who underwent standardized coronary angiography for established or suspected CAD [156 patients with a previous myocardial infarction (MI), 307 without MI]. Four angiographic scores assessing the extent and severity of the coronary lesions were obtained from a double visual analysis of each angiogram, arbitration being achieved by a quantitative measurement. Three different genotypes were analyzed: the angiotensin I-converting enzyme insertion/deletion (ACE I/D) polymorphism, the Met to Thr change at position 235 of the angiotensinogen gene (AGT M235T) and the A to C transition at position 1166 of the angiotensin II type-1 receptor gene (AT1R A1166C). No significant association was observed between these polymorphisms and the clinical characteristics of MI and non-MI subjects. While most classical risk factors were positively correlated with the angiographic scores, no significant relationship could be established with the three genotypes (r ranging from -0.08 to 0.05). Only one significant correlation was observed: between the presence of the AGT 235T allele and the extent of the coronary lesions (r = -0.19, P = 0.04) in patients with low-risk status. These overall results are not in favor of a role of these RAS genetic polymorphisms in the development of coronary atherosclerosis.
肾素-血管紧张素系统（RAS）的基因多态性与冠状动脉疾病（CAD）相关，但这些多态性与冠状动脉粥样硬化之间的关系尚未得到系统评估。CORGENE研究是一项横断面研究，纳入了463名白种人，这些人因确诊或疑似CAD接受了标准化冠状动脉造影[156例既往有心肌梗死（MI）患者，307例无MI患者]。通过对每张血管造影照片进行双盲视觉分析获得了四个评估冠状动脉病变范围和严重程度的血管造影评分，并通过定量测量进行仲裁。分析了三种不同的基因型：血管紧张素I转换酶插入/缺失（ACE I/D）多态性、血管紧张素原基因第235位的甲硫氨酸到苏氨酸变化（AGT M235T）以及血管紧张素II 1型受体基因第1166位的A到C转换（AT1R A1166C）。在这些多态性与MI和非MI受试者的临床特征之间未观察到显著关联。虽然大多数经典危险因素与血管造影评分呈正相关，但与这三种基因型之间未建立显著关系（r范围为-0.08至0.05）。仅观察到一个显著相关性：在低风险状态患者中，AGT 235T等位基因的存在与冠状动脉病变范围之间的相关性（r = -0.19，P = 0.04）。这些总体结果不支持这些RAS基因多态性在冠状动脉粥样硬化发展中的作用。
