Park K D, Lee W K, Yun J Y, Han D K, Kim S H, Kim Y H, Kim H M, Kim K T
Polymer Chemistry Laboratory, Korea Institute of Science and Technology, Seoul, Korea.
Biomaterials. 1997 Jan;18(1):47-51. doi: 10.1016/s0142-9612(96)00096-8.
Biological porcine tissue was modified by the direct coupling of sulphonated poly(ethylene oxide) (PEO-SO3) containing amino acid end groups after glutaraldehyde fixation. The calcification of the modified tissue [bioprosthetic tissue (BT)-PEO-SO3] and control (BT control) was investigated by in vivo rate subdermal, canine aorta-illiac shunt and right ventricle-pulmonary artery shunt implantation models. Less calcium deposition of BT-PEO-SP3 than of BT control was observed in in vivo tests. Such a reduced calcification of BT-PEO-SO3 can be explained by decreases of residual glutaraldehyde groups, a space filling effect and, therefore, improved biostability and synergistic blood-compatible effects of PEO and SO3 groups after the covalent binding of PEO-SO3 to tissue. This simple method can be a useful anti-calcification treatment for implantable tissue valves.
戊二醛固定后，通过含有氨基酸端基的磺化聚环氧乙烷（PEO-SO3）的直接偶联对生物猪组织进行改性。通过体内皮下速率、犬主动脉-髂动脉分流和右心室-肺动脉分流植入模型研究了改性组织[生物假体组织（BT）-PEO-SO3]和对照（BT对照）的钙化情况。在体内试验中观察到BT-PEO-SP3的钙沉积比BT对照少。BT-PEO-SO3钙化的减少可以通过残留戊二醛基团的减少、空间填充效应来解释，因此，在PEO-SO3与组织共价结合后，PEO和SO3基团的生物稳定性和协同血液相容性得到了改善。这种简单的方法可作为植入式组织瓣膜有用的抗钙化治疗方法。
