Kuge Y, Kawashima H, Yamazaki S, Hashimoto N, Miyake Y
Institute for Biofunctional Research, Osaka, Japan.
Nucl Med Biol. 1996 Nov;23(8):1009-12. doi: 10.1016/s0969-8051(96)00148-5.
To evaluate the ability of [1-11C]octanoate as a PET tracer for imaging the brain, we examined its distribution in the brain and surrounding tissues in rats and cats with PET. In rats, owing to the accumulated radioactivity in the harderian glands, clear brain images were not obtained at rostral levels. In cats, the brain was imaged clearly at every level of the coronal brain slices, suggesting the potential of [1-11C]octanoate for imaging the brain.
为评估[1-¹¹C]辛酸作为正电子发射断层显像（PET）示踪剂用于脑成像的能力，我们用PET检测了其在大鼠和猫脑及周围组织中的分布。在大鼠中，由于瞬膜腺中放射性的累积，在脑前部水平未获得清晰的脑图像。在猫中，冠状脑切片的各个层面均能清晰成像，这表明[1-¹¹C]辛酸具有脑成像的潜力。
