Montauban van Swijndregt A D, The S H, Gussenhoven E J, Lancée C T, Rijsterborgh H, de Groot E, van der Steen A F, Bom N, Ackerstaff R G
Department of Radiology, St. Antonius Hospital, Nieuwegein, The Netherlands.
Ultrasound Med Biol. 1996;22(8):1007-15. doi: 10.1016/s0301-5629(96)00130-5.
This in vitro study was executed to evaluate the double line pattern generated at both near and far walls of human carotid arteries using B-mode ultrasound. Therefore, extravascular (7.5 MHz) and intravascular (30 MHz) ultrasound imaging were performed at the same locations of the carotid artery. The thickness of the double line pattern of the extravascular image (7.5 MHz) was compared to the thickness of the intima-media complex seen on the corresponding intravascular image (30 MHz) and on the histologic section. At the far wall of the extravascular image, the measurements were executed at the leading edge of the echo. The data showed high correlation and agreement with the intravascular (r = 0.91, p < 0.001; mean(diff) = -0.01 and SDdiff = 0.12) and the histologic measurements (r = 0.87, p < 0.001; mean(diff) = -0.12 and SDdiff = 0.13). In addition, the results of the measurements of the intravascular image showed high correlations and agreement with the histologic data (r(near) = 0.86, p < 0.001; mean(diff) = -0.08 and SDdiff = 0.15, respectively, r(far) = 0.92, p < 0.001; mean(diff) = -0.12 and SDdiff = 0.12). For comparison with other studies, near wall measurements were also included. These had to be performed at the trailing edge of the echoes to be compatible with these studies. The results of the measurements of the extravascular image showed poor correlations and lack of agreement with those of the intravascular (r = 0.49, p = 0.03; mean(diff) = 0.09 and SDdiff = 0.25) and of the histologic (r = 0.37, p = 0.03; mean(diff) = 0.04 and SDdiff = 0.23) measurements. These results can easily be explained from the physical limitations of measuring at the trailing edges. We conclude that the double line pattern seen at the far wall of the extravascular image is representative of the intima-media complex.
本体外研究旨在使用B型超声评估人类颈动脉近壁和远壁产生的双线模式。因此，在颈动脉的相同位置进行了血管外（7.5 MHz）和血管内（30 MHz）超声成像。将血管外图像（7.5 MHz）的双线模式厚度与相应血管内图像（30 MHz）和组织学切片上看到的内膜-中膜复合体厚度进行比较。在血管外图像的远壁处，测量在回声的前沿进行。数据显示与血管内测量（r = 0.91，p < 0.001；平均差异（mean(diff)）= -0.01，标准差差异（SDdiff）= 0.12）和组织学测量（r = 0.87，p < 0.001；mean(diff) = -0.12，SDdiff = 0.13）具有高度相关性和一致性。此外，血管内图像的测量结果与组织学数据显示出高度相关性和一致性（近壁处r(near) = 0.86，p < 0.001；mean(diff) = -0.08，SDdiff = 0.15；远壁处r(far) = 0.92，p < 0.001；mean(diff) = -0.12，SDdiff = 0.12）。为了与其他研究进行比较，还包括了近壁测量。为了与这些研究兼容，这些测量必须在回声的后沿进行。血管外图像的测量结果与血管内测量（r = 0.49，p = 0.03；mean(diff) = 0.09，SDdiff = 0.25）和组织学测量（r = 0.37，p = 0.03；mean(diff) = 0.04，SDdiff = 0.23）的相关性较差且缺乏一致性。这些结果可以很容易地从在后沿测量的物理限制中得到解释。我们得出结论，血管外图像远壁处看到的双线模式代表内膜-中膜复合体。
