Guo Z, Fenster A
Imaging Research Laboratories, John P. Robarts Research Institute, London, Ontario, Canada.
Ultrasound Med Biol. 1996;22(8):1059-69. doi: 10.1016/s0301-5629(96)00125-1.
This study investigated whether three-dimensional (3D) power Doppler imaging can be used to quantify arterial stenosis and its potential as an alternative to x-ray angiography. Three-dimensional power Doppler images of in vitro stenotic vessels were generated under different hemodynamic conditions with a 3D power Doppler imaging system. This system includes: a Macintosh Quadra 840AV computer used to perform 3D imaging acquisition, reconstruction and display; a computer-controlled motor-driven translation assembly used to move the transducer; and an ATL Ultramark 9 HDI ultrasound system. Three vascular- and tissue-mimicking phantoms containing three wall-less stenotic vessels with area reduction of 80%, 50% and 30% were imaged with different flow rates under both steady and pulsatile flow conditions and with different Doppler angles under steady flow condition. With the use of the blood mimic, experimental results demonstrated that power Doppler imaging is nearly independent on flow velocity and Doppler angle. It was also demonstrated that 3D power Doppler imaging can produce nonpulsatile angiographic-like 3D images of the flow field. The stenotic vessels were quantified with an overall accuracy of 8.3% of the vessel area and an overall precision of 7% of the vessel area under the conditions described in this paper. It is believed that 3D power Doppler imaging can be used to quantify arterial stenosis, and in some applications it could be an alternative to x-ray angiography.
本研究调查了三维（3D）能量多普勒成像是否可用于量化动脉狭窄及其作为X射线血管造影替代方法的潜力。使用3D能量多普勒成像系统在不同血流动力学条件下生成体外狭窄血管的三维能量多普勒图像。该系统包括：一台用于执行三维成像采集、重建和显示的Macintosh Quadra 840AV计算机；一个用于移动换能器的计算机控制的电动平移组件；以及一台ATL Ultramark 9 HDI超声系统。对三个含有三个无壁狭窄血管的血管和组织模拟体模进行成像，这些血管的面积减少分别为80%、50%和30%，在稳定和脉动血流条件下以不同流速成像，并在稳定血流条件下以不同多普勒角度成像。使用血液模拟物的实验结果表明，能量多普勒成像几乎与流速和多普勒角度无关。还证明了三维能量多普勒成像可以生成流场的非脉动血管造影样三维图像。在本文所述条件下，对狭窄血管进行量化的总体准确率为血管面积的8.3%，总体精密度为血管面积的7%。人们认为三维能量多普勒成像可用于量化动脉狭窄，并且在某些应用中它可以替代X射线血管造影。
