故意甲基溴中毒后的死亡：毒理学数据及文献综述

Death following intentional methyl bromide poisoning: toxicological data and literature review.

作者信息

Michalodimitrakis M N, Tsatsakis A M, Christakis-Hampsas M G, Trikilis N, Christodoulou P

机构信息

Department of Forensic Pathology, Medical School, University of Crete, Heraklion, Voutes, Greece.

出版信息

Vet Hum Toxicol. 1997 Feb;39(1):30-4.

PMID:9004465

Abstract

A case of fatal poisoning due to ingestion-inhalation of methyl bromide (MeBr) is presented. In previously reported fatalities due to MeBr inhalation, only inorganic bromide levels in biological specimens were reported. Intact MeBr has not been isolated from human tissues following exposure. In the present case, MeBr was detected, confirmed and quantitated in various biological samples by headspace gas chromatography, and the clinical manifestations and autopsy findings are described. Postmortem MeBr peripheral blood concentration was 3.3 micrograms/mL and in subclavian blood was 3.8 micrograms/mL. Lung, brain, adrenal gland, kidney, liver and testis MeBr was 2.9, 3.5, 3.4, 2.6, 1.9 and 2.8 micrograms/g respectively; MeBr in bile was 1.2 micrograms/mL. Inorganic bromide concentrations were 530, 30, 310 and 130 micrograms/g in blood, brain, kidney and adrenal gland respectively.

摘要

本文报告了一例因吸入和摄入甲基溴（MeBr）导致的致命中毒病例。在先前报道的因吸入MeBr导致的死亡病例中，仅报告了生物样本中的无机溴水平。暴露后，尚未从人体组织中分离出完整的MeBr。在本病例中，通过顶空气相色谱法在各种生物样本中检测、确认并定量了MeBr，并描述了临床表现和尸检结果。死后外周血中MeBr浓度为3.3微克/毫升，锁骨下血中为3.8微克/毫升。肺、脑、肾上腺、肾、肝和睾丸中的MeBr分别为2.9、3.5、3.4、2.6、1.9和2.8微克/克；胆汁中的MeBr为1.2微克/毫升。血液、脑、肾和肾上腺中的无机溴浓度分别为530、30、310和130微克/克。