Tanaka T, Kasai K, Kita T, Tanaka N
Department of Forensic Medicine, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.
J Forensic Sci. 1998 Sep;43(5):1086-8.
A victim who was presumed to have ingested waste fluid containing phenol of DNA extraction was found dead in his laboratory. The skin was partially chemically burned, with blisters as maps. No mechanical injuries were observed. The pathological findings of the liver and kidney were typical of those of acute substantial poisoning. Phenol concentrations in the blood, urine, stomach contents and organs were determined by gas chromatography/mass spectrometry. Phenol was distributed throughout the body. The concentration of free phenol in the blood was found to be 60 micrograms/mL, and in the urine it was 208 micrograms/mL. The phenol concentrations in the organs were found as follows: 106 micrograms/g in the brain; 116 micrograms/g in the lungs; 166 micrograms/g in the liver, and 874 micrograms/g in the kidney, respectively. Significantly high concentrations were observed in the kidney, urine, and liver. To the best of our knowledge, such an intoxication through this kind of ingestion has never been reported before. Distributions of phenol in fatal poisonings have been reported, but colorimetry was used as the analytical method and it cannot exclude the interference of other phenolic compounds.
一名被推测摄入用于DNA提取的含苯酚废液的受害者被发现死于其实验室。皮肤有部分化学灼伤，水泡呈地图状。未观察到机械性损伤。肝脏和肾脏的病理表现为典型的急性实质性中毒。通过气相色谱/质谱法测定了血液、尿液、胃内容物和器官中的苯酚浓度。苯酚分布于全身。血液中游离苯酚浓度为60微克/毫升，尿液中为208微克/毫升。各器官中的苯酚浓度如下：大脑中为106微克/克；肺中为116微克/克；肝脏中为166微克/克，肾脏中为874微克/克。在肾脏、尿液和肝脏中观察到显著高的浓度。据我们所知，此前从未有过通过这种摄入方式导致中毒的报道。已有关于致命中毒中苯酚分布的报道，但采用的分析方法是比色法，且无法排除其他酚类化合物的干扰。
