Cloyd M W, Hartley J W, Rowe W P
J Exp Med. 1981 Aug 1;154(2):450-7. doi: 10.1084/jem.154.2.450.
The mink cell focus-inducing (MCF)-247 virus, originally isolated from an AKR thymoma, is lymphomagenic in AKR mice but not in the ecotropic virus-negative NFS mouse strain. Analysis of sensitivity to lymphoma-induction by AKR-247 MCF virus in genetic hybrids between these two strains showed that F1 mice inoculated as sucklings were uniformly sensitive, whereas those inoculated as weanlings were generally resistant. In NFS backcross mice inoculated as sucklings, inheritance and expression of endogenous ecotropic virus from AKR was an essential correlate of replication of MCF virus and subsequent development of lymphoma. However, one-third of the mice expressing ecotropic virus and replicating the inoculated MCF virus did not develop lymphoma. The results suggested that an additional gene that influenced development of lymphoma may be involved, and that mice inheriting both virus-inducing loci from AKR were more susceptible than those inheriting only one. These findings indicate that the causal role of ecotropic virus infection in spontaneous thymomagenesis in AKR mice involves not only the generation of leukemogenic MCF viruses but also the establishment of permissiveness for their growth.
貂细胞融合诱导（MCF）-247病毒最初从AKR胸腺瘤中分离得到，它在AKR小鼠中具有致淋巴瘤性，但在亲嗜性病毒阴性的NFS小鼠品系中则无此特性。对这两个品系之间的遗传杂交后代进行AKR - 247 MCF病毒诱导淋巴瘤敏感性分析表明，哺乳时接种的F1小鼠均具有敏感性，而断奶时接种的小鼠通常具有抗性。在哺乳时接种的NFS回交小鼠中，来自AKR的内源性亲嗜性病毒的遗传和表达是MCF病毒复制及随后淋巴瘤发生的重要相关因素。然而，三分之一表达亲嗜性病毒并复制接种的MCF病毒的小鼠并未发生淋巴瘤。结果提示，可能存在一个影响淋巴瘤发生的额外基因，并且从AKR继承两个病毒诱导位点的小鼠比仅继承一个位点的小鼠更易患病。这些发现表明，亲嗜性病毒感染在AKR小鼠自发性胸腺瘤发生中的因果作用不仅涉及致白血病性MCF病毒的产生，还涉及其生长允许性的建立。
