Baldellou Vázquez A, Gomá Brufau A, Vargas Torcal F, Pastor Mourón I, Ros Mar L, Ferrández Longás A
An Esp Pediatr. 1977 May;10(5):441-6.
In order to know if small children subjected to a long-term treatment with phenobarbital can suffer some alterations in their lineal growth or in their osseous maturity in the same way as those showed by epileptical mother's sons, 85 patients between six months and three years old, who had suffered fit convulsions during a fever process, 20 of them subjected to antithermic treatment, and the 65 left who received a phenobarbital treatment in doses of 5 mg./kg./day have been controlled. In each child, at the beginning of the control and after 12 months, their height, diaphysial diameter and cortical thickness of the metacarpal bones, and bone age is valued. At the same time a calcium, phosphorous and phosphatase-alcaline control was done. The group who had received anti-convulsivants drugs, showed a significant decrease in their lineal growth and in calcium concentration in blood. The control group didn't present any significant variation in any of the controls performed.
为了了解长期接受苯巴比妥治疗的幼儿是否会像癫痫母亲的儿子那样出现线性生长或骨成熟方面的某些改变，对85名6个月至3岁在发热过程中发生惊厥的患儿进行了对照研究，其中20名接受退热治疗，其余65名接受5毫克/千克/天剂量的苯巴比妥治疗。在每个孩子对照开始时和12个月后，对他们的身高、掌骨骨干直径和皮质厚度以及骨龄进行评估。同时进行了钙、磷和碱性磷酸酶的对照检测。接受抗惊厥药物治疗的组在其线性生长和血液中钙浓度方面显示出显著下降。对照组在进行的任何一项对照检测中均未出现任何显著变化。
