Filippi M, Yousry T, Horsfield M A, Alkadhi H, Rovaris M, Campi A, Voltz R, Comi G
Department of Neurology, Scientific Institute Ospedale San Raffaele, University of Milan, Italy.
Ann Neurol. 1996 Dec;40(6):901-7. doi: 10.1002/ana.410400612.
In this study, we performed a post-contrast magnetization-prepared rapid acquisition gradient echo (MP RAGE) sequence with subsequent reconstruction of axial slices with 5-, 3-, and 1-mm thickness in 26 patients with multiple sclerosis (MS) to investigate the disease activity going on below the resolution of conventional scans. One hundred three enhancing lesions were detected using MP RAGE reconstructed with 1-mm-thick slices, 93 using MP RAGE reconstructed with 3-mm-thick slices and 82 using MP RAGE reconstructed with 5-mm-thick slices. The detection rate using 1-mm MP RAGE was 25.6% higher compared with 5-mm MP RAGE and 12% higher compared with 3-mm MP RAGE. Using 1-mm MP RAGE, we detected five enhancing lesions in 2 of the 12 patients (16.6%) who showed no enhancing lesions on the 5-mm MP RAGE and one enhancing lesion in 1 of the 10 patients (10%) who showed no enhancing lesions on the 3-mm MP RAGE. The increased sensitivity of 1-mm MP RAGE over the other two reconstruction slice thicknesses was due to improved detection of small lesions, located mainly in cortical/subcortical areas. These data indicate that the size of enhancing lesions in MS is highly variable, and that a significant proportion of disease activity goes undetected when performing conventional scans.
在本研究中，我们对26例多发性硬化症（MS）患者进行了对比剂增强后的磁化准备快速采集梯度回波（MP RAGE）序列检查，并随后重建了厚度为5毫米、3毫米和1毫米的轴向切片，以研究常规扫描分辨率以下正在进行的疾病活动情况。使用1毫米厚切片重建的MP RAGE检测到103个强化病灶，使用3毫米厚切片重建的MP RAGE检测到93个，使用5毫米厚切片重建的MP RAGE检测到82个。与5毫米MP RAGE相比，1毫米MP RAGE的检测率高25.6%，与3毫米MP RAGE相比高12%。使用1毫米MP RAGE，我们在12例在5毫米MP RAGE上未显示强化病灶的患者中的2例（16.6%）检测到5个强化病灶，在10例在3毫米MP RAGE上未显示强化病灶的患者中的1例（10%）检测到1个强化病灶。1毫米MP RAGE相对于其他两种重建切片厚度的敏感性增加是由于对主要位于皮质/皮质下区域的小病灶检测得到改善。这些数据表明，MS中强化病灶的大小高度可变，并且在进行常规扫描时，相当一部分疾病活动未被检测到。
