Khan F, Wessely Z, Chazin S R, Seriff N S
Ann Ophthalmol. 1977 May;9(5):671-6.
A prospective study was undertaken to determine the prevalence and specificity of granulomatous conjunctivitis in sarcoidosis. One hundred conjunctival biopsies were performed on patients with histologically confirmed sarcoidosis (60), pulmonary tuberculosis (25), and several nonspecific inflammatory diseases of the lung and eye (15). A positive biopsy was present in 33% of the patients with sarcoidosis, but in none of the other disease processes. Great care was taken to exclude the possibility of these granulomas being secondary to foreign body reaction or infection with tuberculosis or fungi. No predictive relationship could be established between eye symptoms or slit lamp findings in the conjunctiva and uveal tract, and the finding of positive conjunctival biopsies. Thus, it is suggested that this procedure, due to its ease, safety, and specificity, be the first biopsy performed in patients with clinical or chest x-ray abnormalities suggesting sarcoidosis.
进行了一项前瞻性研究，以确定结节病中肉芽肿性结膜炎的患病率和特异性。对组织学确诊为结节病的患者（60例）、肺结核患者（25例）以及几种肺部和眼部非特异性炎症性疾病患者（15例）进行了100次结膜活检。结节病患者中有33%的活检结果呈阳性，而其他疾病过程的患者均未出现阳性结果。已格外小心地排除了这些肉芽肿继发于异物反应或结核或真菌感染的可能性。结膜和葡萄膜的眼部症状或裂隙灯检查结果与结膜活检阳性结果之间无法建立预测关系。因此，建议由于该检查操作简便、安全且具有特异性，应作为对临床或胸部X光检查异常提示结节病的患者进行的首次活检。
