Spaide R F, Ward D L
Ophthalmology Service, Landstuhl Army Regional Medical Center, West Germany.
Br J Ophthalmol. 1990 Aug;74(8):469-71. doi: 10.1136/bjo.74.8.469.
We prospectively studied 47 sarcoidosis suspects and compared conjunctival and transbronchial lung biopsies in these patients. Thirty-four patients had positive findings on biopsy by either method. The transbronchial biopsy was positive in 31 patients, and the conjunctival was positive in 19. The transbronchial lung biopsy was more likely to be positive in black patients (p = 0.009) and in patients with pulmonary infiltrates on chest x ray (p = 0.0044). In comparison, the conjunctival biopsy was more likely to be positive in patients with conjunctival follicles (p = 0.036), ocular abnormalities consistent with sarcoidosis (p = 0.02), and in patients with pulmonary infiltrates on chest x ray (p = 0.029). Iritis was present in 12 patients, enlarged lacrimal glands in three, and vitritis in five. We conclude that the conjunctival biopsy is an effective means of diagnosing sarcoidosis and that every sarcoidosis patient should have an ophthalmic examination.
我们对47名结节病疑似患者进行了前瞻性研究，并比较了这些患者的结膜活检和经支气管肺活检结果。34名患者通过两种方法中的任何一种活检均有阳性发现。经支气管活检31例阳性，结膜活检19例阳性。经支气管肺活检在黑人患者中更易呈阳性（p = 0.009），在胸部X线有肺部浸润的患者中更易呈阳性（p = 0.0044）。相比之下，结膜活检在有结膜滤泡的患者中更易呈阳性（p = 0.036），在有符合结节病的眼部异常的患者中更易呈阳性（p = 0.02），在胸部X线有肺部浸润的患者中也更易呈阳性（p = 0.029）。12例患者有虹膜炎，3例泪腺肿大，5例有玻璃体炎。我们得出结论，结膜活检是诊断结节病的有效方法，每位结节病患者都应接受眼科检查。
