Harrell D S, Kozlowski M, Katz M D, Hanks S E
Department of Radiology, University of Southern California, Los Angeles, USA.
J Vasc Interv Radiol. 1996 Mar-Apr;7(2):193-7. doi: 10.1016/s1051-0443(96)70761-3.
To determine whether the addition of heparin to urokinase during dialysis graft thrombolysis can lower urokinase dose and shorten procedure time.
Patients who underwent dialysis graft thrombolysis during an 18-month period were studied retrospectively. Twenty patients were treated with urokinase alone, and 19 patients were treated with urokinase and heparin. Thrombolysis was performed in the angiography suite by using a crossed-catheter technique. Urokinase was administered directly into the thrombus. In patients receiving heparin, 5,000 IU was added directly to the initial urokinase solution.
In patients who received urokinase alone, an average of 750,000 U of urokinase was used, and the average procedure time was 2 hours 42 minutes. When heparin was added, an average of 435,000 U of urokinase was used, and the average procedure time was 2 hours.
The addition of heparin to urokinase can decrease both urokinase dose and thrombolysis time in the recanalization of dialysis grafts.
确定在透析移植血管溶栓过程中，尿激酶加入肝素是否能降低尿激酶剂量并缩短操作时间。
回顾性研究18个月期间接受透析移植血管溶栓的患者。20例患者仅接受尿激酶治疗，19例患者接受尿激酶和肝素治疗。在血管造影室采用交叉导管技术进行溶栓。尿激酶直接注入血栓。接受肝素治疗的患者，5000国际单位直接加入初始尿激酶溶液中。
仅接受尿激酶治疗的患者，平均使用尿激酶750000单位，平均操作时间为2小时42分钟。加入肝素后，平均使用尿激酶435000单位，平均操作时间为2小时。
尿激酶中加入肝素可降低透析移植血管再通时的尿激酶剂量和溶栓时间。
