透析通路移植物溶栓：脉冲式喷射与尿激酶持续输注的随机研究。
Dialysis access graft thrombolysis: randomized study of pulse-spray versus continuous urokinase infusion.
作者信息
Goodwin S C, Arora L C, Razavi M K, Sayre J, McNamara T O, Yoon C
机构信息
Department of Radiological Sciences, UCLA School of Medicine, Center for the Health Sciences, BL-423, 10833 LeConte Avenue, Los Angeles, CA 90095-1721, USA.
出版信息
Cardiovasc Intervent Radiol. 1998 Mar-Apr;21(2):135-7. doi: 10.1007/s002709900229.
PURPOSE
To compare pulse-spray to continuous-infusion thrombolysis with high-dose urokinase in thrombosed dialysis access grafts.
METHODS
A prospective randomized controlled trial was performed. From August 1992 to September 1993, 30 thrombosed polytetrafluoroethylene (PTFE) grafts in 24 patients were included, 15 grafts in each group. The success of thrombolysis, mean time to thrombolysis, mean urokinase dose, and 60-day patency rate were evaluated.
RESULTS
In the pulse-spray group, the mean time to thrombolysis was 72 min with a mean urokinase dose of 560,000 U. The 60-day patency rate was 71%. In the continuous-infusion group, the mean infusion time to thrombolysis was 55 min with a mean dose of 479,000 U. The 60-day patency rate was 73%.
CONCLUSION
No statistically significant difference was found between the two techniques in the mean time to thrombolysis, the mean urokinase dose used, or the 60-day patency rate.
目的
比较脉冲喷射溶栓与大剂量尿激酶持续输注溶栓治疗血栓形成的透析通路移植物的效果。
方法
进行一项前瞻性随机对照试验。1992年8月至1993年9月，纳入24例患者的30条血栓形成的聚四氟乙烯（PTFE）移植物，每组15条移植物。评估溶栓成功率、平均溶栓时间、平均尿激酶剂量和60天通畅率。
结果
脉冲喷射组平均溶栓时间为72分钟，平均尿激酶剂量为560,000 U。60天通畅率为71%。持续输注组平均溶栓输注时间为55分钟，平均剂量为479,000 U。60天通畅率为73%。
结论
两种技术在平均溶栓时间、所用平均尿激酶剂量或60天通畅率方面均未发现统计学上的显著差异。
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