Spranger M, Schwab S, Meinck H M, Tischendorf M, Sis J, Breitbart A, Andrassy K
Department of Neurology, University of Heidelberg, Germany.
Neurology. 1997 Jan;48(1):263-5. doi: 10.1212/wnl.48.1.263.
MRI and CSF investigations revealed meningeal involvement in a 29-year-old patient with biopsy-confirmed Wegener's granulomatosis. The intracranial manifestation of Wegener's granulomatosis was supported by the detection of pathologic circulating antineutrophil cytoplasm (c-ANCA) in the CSF. We monitored disease activity by c-ANCA measurement in the CSF. After repeated cycles of intrathecal administration of methotrexate and corticoids, progression of meningeal infiltration stopped, and CSF c-ANCA titers became negative.
磁共振成像（MRI）和脑脊液检查显示，一名经活检确诊为韦格纳肉芽肿的29岁患者存在脑膜受累情况。脑脊液中检测到病理性循环抗中性粒细胞胞浆抗体（c-ANCA），支持了韦格纳肉芽肿的颅内表现。我们通过检测脑脊液中的c-ANCA来监测疾病活动情况。在反复鞘内注射甲氨蝶呤和皮质类固醇后，脑膜浸润进展停止，脑脊液c-ANCA滴度转为阴性。
