Kluger A, Gianutsos J G, Golomb J, Ferris S H, George A E, Franssen E, Reisberg B
Department of Psychiatry, New York University Medical Center, USA.
J Gerontol B Psychol Sci Soc Sci. 1997 Jan;52B(1):P28-39. doi: 10.1093/geronb/52b.1.p28.
In order to determine the relationship between cognitive dysfunction and motor behavior in older adults, 41 cognitively normal elderly (NL), 25 cases exhibiting mild cognitive impairment (MI), and 25 patients with mild Alzheimer's disease (AD) were examined using a broad array to motor/psychomotor and cognitive tests. Relative to the NL group, MI individuals (at risk for future decline to AD) performed worse on tasks involving fine and complex motor function (e.g., tracking and manual dexterity). AD patients also exhibited motor dysfunction on tasks assessing relatively more rudimentary motor control. Motor tasks were able to distinguish NL vs MI and NL vs mild AD individuals as effectively as cognitive tests of memory and language. These results indicate that motor impairment is an important aspect of cognitive decline in older adults. Motor/psychomotor assessments may be comparably sensitive to traditional tests of cognitive function in identifying persons affected by the earliest stages of AD pathology.
为了确定老年人认知功能障碍与运动行为之间的关系，我们使用一系列广泛的运动/心理运动和认知测试，对41名认知正常的老年人（NL）、25例表现为轻度认知障碍（MI）的患者以及25例轻度阿尔茨海默病（AD）患者进行了检查。相对于NL组，MI个体（未来有发展为AD风险）在涉及精细和复杂运动功能的任务（如跟踪和手部灵活性）上表现更差。AD患者在评估相对更基本运动控制的任务中也表现出运动功能障碍。运动任务在区分NL与MI以及NL与轻度AD个体方面，与记忆和语言的认知测试同样有效。这些结果表明，运动障碍是老年人认知衰退的一个重要方面。在识别受AD病理早期阶段影响的人群时，运动/心理运动评估可能与传统认知功能测试同样敏感。
