Chauvin A, Boulard C
Département de Pathologie générale, infectieuse et parasitaire, Ecole Nationale Vétérinaire, Nantes, France.
Parasite. 1996 Sep;3(3):209-15. doi: 10.1051/parasite/1996033209.
Macrophages, eosinophils, neutrophils and lymphocyte subpopulations (OvCD5+, OvCD4+, OvCD8+, OvWC1+ and lg+) were identified in sections of hepatic tissue and hepatic lymph nodes from sheep experimentally infected with F. hepatica and necropsied 14, 28, 42 or 56 days post infection. The migratory tunnels produced by juvenile flukes appeared as local areas of necrosis surrounded by infiltrating inflammatory cells, particularly numerous macrophages, eosinophils and OvCD4+ lymphocytes n addition, B lymphocyte proliferation was observed in hepatic lymph nodes and in hepatic portal tracts. Only three juvenile flukes were identified in the sections. They where partially in contact with healthy tissue and partially with neutrophils, macrophages and eosinophils; they were covered by IgM Host-parasite interactions resulting from immune response regulation by helper T lymphocytes and from immune evasion by the parasite are discussed.
在实验感染肝片吸虫并于感染后14、28、42或56天进行剖检的绵羊的肝组织和肝淋巴结切片中，鉴定出了巨噬细胞、嗜酸性粒细胞、中性粒细胞和淋巴细胞亚群（OvCD5 +、OvCD4 +、OvCD8 +、OvWC1 +和Ig +）。由幼虫吸虫产生的迁移隧道表现为局部坏死区域，周围有浸润的炎性细胞，特别是大量巨噬细胞、嗜酸性粒细胞和OvCD4 +淋巴细胞。此外，在肝淋巴结和肝门区观察到B淋巴细胞增殖。切片中仅鉴定出三只幼虫吸虫。它们部分与健康组织接触，部分与中性粒细胞、巨噬细胞和嗜酸性粒细胞接触；它们被IgM覆盖。讨论了由辅助性T淋巴细胞调节免疫反应以及寄生虫免疫逃避导致的宿主 - 寄生虫相互作用。
