Moreau Emmanuelle, Chauvin Alain
UMR ENVN/INRA 1300 Bioagression, Epidémiologie et Analyse de Risques, Atlanpole-La Chantrerie, 44307 Nantes, France.
J Biomed Biotechnol. 2010;2010:428593. doi: 10.1155/2010/428593. Epub 2010 Feb 3.
Helminth parasites are of considerable medical and economic importance. Studies of the immune response against helminths are of great interest in understanding interactions between the host immune system and parasites. Effector immune mechanisms against tissue-dwelling helminths and helminths localized in the lumen of organs, and their regulation, are reviewed. Helminth infections are characterized by an association of Th2-like and Treg responses. Worms are able to persist in the host and are mainly responsible for chronic infection despite a strong immune response developed by the parasitized host. Two types of protection against the parasite, namely, premune and partial immunities, have been described. Immune responses against helminths can also participate in pathogenesis. Th2/Treg-like immunomodulation allows the survival of both host and parasite by controlling immunopathologic disorders and parasite persistence. Consequences of the modified Th2-like responses on co-infection, vaccination, and inflammatory diseases are discussed.
蠕虫寄生虫具有相当大的医学和经济重要性。针对蠕虫的免疫反应研究对于理解宿主免疫系统与寄生虫之间的相互作用具有极大的意义。本文综述了针对寄生于组织内的蠕虫以及寄生于器官管腔内的蠕虫的效应免疫机制及其调节。蠕虫感染的特征是类似Th2和调节性T细胞（Treg）反应的联合。尽管被寄生的宿主产生了强烈的免疫反应，但蠕虫仍能够在宿主体内持续存在，并主要导致慢性感染。已经描述了两种针对寄生虫的保护类型，即预免疫和部分免疫。针对蠕虫的免疫反应也可能参与发病机制。类似Th2/Treg的免疫调节通过控制免疫病理紊乱和寄生虫的持续存在，使宿主和寄生虫都得以存活。本文还讨论了改变的类似Th2反应对合并感染、疫苗接种和炎症性疾病的影响。
