Black J G, Lawson K F
Can J Comp Med. 1980 Apr;44(2):169-76.
Foxes given ERA rabies vaccine baits were challenged at one, six, 12 and 24 months later and showed a resistance to challenge in 80%, 78%, 60% and 44% of individuals respectively. All animals showing seroconversion following vaccination, resisted challenge at 24 months, suggesting that successful vaccination by the oral route could confer a relatively long term duration of immunity. The trials showed that fox pups did not immunize as easily as adult foxes using ERA rabies vaccine baits. Back-passage studies and the consumption of ERA injected mice by foxes failed to show any reversion of the vaccine virus to a virulent state. The fox and mouse are shown to be highly susceptible to rabies street virus, while the domestic species tested are consisderably more resistant. Monkeys were found to be intermediate in susceptibility to the virus. Safety tests carried out on various species of wildlife showed only the mouse to be susceptible to infection from ingesting the vaccine in the form of a bait. ERA rabies vaccine was shown to be safe in monkeys even when high titred virus was administered by the oral route.
给狐狸投喂ERA狂犬病疫苗诱饵后，分别在1个月、6个月、12个月和24个月后对它们进行攻毒，结果显示分别有80%、78%、60%和44%的个体对攻毒具有抵抗力。所有接种疫苗后出现血清转化的动物在24个月时都抵抗了攻毒，这表明通过口服途径成功接种疫苗可赋予相对长期的免疫力。试验表明，使用ERA狂犬病疫苗诱饵时，幼狐不像成年狐那样容易产生免疫。狐狸对注射ERA的小鼠的传代研究和食用情况未能显示疫苗病毒有任何回复为强毒株状态的情况。狐狸和小鼠对狂犬病街毒高度易感，而所检测的家养物种则具有相当强的抵抗力。发现猴子对该病毒的易感性处于中间水平。对各种野生动物进行的安全性试验表明，只有小鼠在摄食诱饵形式的疫苗时易受感染。即使通过口服途径给予高滴度病毒，ERA狂犬病疫苗在猴子中也显示是安全的。
