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[巴西东南部一个大都市地区人群中的动脉粥样硬化性心血管疾病、血脂异常、高血压、肥胖症和糖尿病。II--血脂异常]

[Atherosclerotic cardiovascular disease, lipemic disorders, hypertension, obesity and diabetes mellitus in the population of a metropolitan area of southeastern Brazil. II--Lipemic disorders].

作者信息

Martins I S, Marucci M de F, Cervato A M, Okani E T, Mazzilli R N, Casajus M I

机构信息

Departamento de Nutrição da Faculdade de Saúde Pública., São Paulo, Brasil.

出版信息

Rev Saude Publica. 1996 Feb;30(1):75-84. doi: 10.1590/s0034-89101996000100010.

DOI:10.1590/s0034-89101996000100010
PMID:9008925
Abstract

This study has sought to characterize the prevalence of lipemic disorders and other risk factors of atheroschlerotic cardiovascular disease in population groups of Cotia county in Greater S. Paulo, Brazil. The population groups were defined on the basis of socio-economic characteristics and geographical location within the county such as provided elements for the delimitation of the "study areas". A sample representative of each of these areas was taken, constituting in all 1,041 individuals. The data related to eating habits were collected from a sub-sample of 568 people. The lipemic disorders diagnosed were as follows: high risk hypercholesterolemias with values approximately 240 mg/dl for total cholesterol and approximately 160 mg/dl for LDL-cholesterol; borderline risk hypercholesterolemias with values > 200 mg/dl and > 130 mg/dl for total cholesterol and LDL-cholesterol respectively; hypertriglyceridemia, with values approximately 250 mg/dl. The following risk factors were included: atherogenic eating habits (consumption of proteins of animal origin, saturated fats and cholesterol), smoking, drinking, sedentary life style, obesity (IMC > 25 kg/m2), hypertension (140/90 mmHg) and diabetes mellitus (glycemia > 120 mg/dl). The results found were the following: 1--the average number of risk factors was significant by greater among men than among women, for the age groups below 50 years of age (p < 0.01): between 50 and 55 years of age they were equal for the two groups, reaching their greatest value at 60 years of age with a sharp reduction after this latter age as regard the men but presenting a constant gradual increase for the women; 2--the average number of risk factors increased with age for both sexes (p < 0.01); 3--the prevalences of high risk hypercholesterolemias together with hypertriglyceridemia (> = 250 mg/dl) were significantly greater in the classes of higher socio-economic level; 4--the lipemic profile associated with lipemic disorders show that these latter rarely occur with just one constituent in isolation; 5--when the high-risk hypercolesterolemias are added to the borderline cases accompanied by two or more risk factors and hypertriglyceridemia they give a total of 39.2% of men and 32.8% of women, that is to say, 35.4% of the sample need immediate clinical-educational intervention.

摘要

本研究旨在描述巴西大圣保罗科蒂亚县人群中血脂异常及动脉粥样硬化性心血管疾病其他危险因素的流行情况。人群分组是根据该县的社会经济特征和地理位置确定的,这些因素为划定“研究区域”提供了依据。从这些区域中各抽取了一个具有代表性的样本,共1041人。与饮食习惯相关的数据是从568人的子样本中收集的。诊断出的血脂异常情况如下:高危高胆固醇血症,总胆固醇值约为240mg/dl,低密度脂蛋白胆固醇值约为160mg/dl;边缘性高危高胆固醇血症,总胆固醇值>200mg/dl,低密度脂蛋白胆固醇值>130mg/dl;高甘油三酯血症,值约为250mg/dl。纳入的危险因素如下:致动脉粥样硬化饮食习惯(食用动物源性蛋白质、饱和脂肪和胆固醇)、吸烟、饮酒、久坐生活方式、肥胖(体质指数>25kg/m²)、高血压(140/90mmHg)和糖尿病(血糖>120mg/dl)。研究结果如下:1. 在50岁以下年龄组中,男性的平均危险因素数量显著多于女性(p<0.01);在50至55岁之间,两组的平均危险因素数量相等;在60岁时达到最大值,此后男性的平均危险因素数量急剧下降,而女性则持续逐渐增加;2. 男女的平均危险因素数量均随年龄增长而增加(p<0.01);3. 高危高胆固醇血症和高甘油三酯血症(>=250mg/dl)在社会经济水平较高的阶层中患病率显著更高;4. 与血脂异常相关的血脂谱表明,这些血脂异常很少仅由一种成分单独出现;5. 当将高危高胆固醇血症与伴有两个或更多危险因素的边缘性病例以及高甘油三酯血症相加时,男性占39.2%,女性占32.8%,也就是说,35.4%的样本需要立即进行临床教育干预。

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