Park Y, Lee H, Koh C S, Min H
Department of Internal Medicine, Hanyang University College of Medicine, Seoul, South Korea.
Diabetes Res Clin Pract. 1996 Oct;34 Suppl:S65-72. doi: 10.1016/s0168-8227(96)90010-8.
The present study was undertaken to determine the prevalence of hyperlipidemia and to find out the possible impact of serum lipid profiles on other cardiovascular risk factors in Yonchon County, Korea. Population-based cross-sectional study by random cluster sampling of registered residents over 30 years of age was performed. Out of the 3804 subjects scheduled for the survey, 2520 underwent the actual examination. The prevalence of hypercholesterolemia (serum cholesterol > or = 240 mg/dl) was only 1.2%, whereas that of hypertriglyceridemia (serum triglyceride > or = 250 mg/dl) was as high as 11.3%. The serum levels of cholesterol, triglyceride and HDL cholesterol correlated with anthropometric indices, body mass indices and waist hip ratios. The prevalences of diabetes and/or hypertension increased as either serum cholesterol or triglyceride level increased. In addition, the prevalence rates of obesity, impaired glucose tolerance, hypertriglyceridemia and hypercholesterolemia in its isolated form (free of the others) were much lower than overall prevalence indicating an existence of major overlap among these cardiovascular atherosclerotic risk factors in the form of multiple combinations. Central obesity was found to be an independent associated factor for the aggregation of the conditions related to the increase in cardiovascular risks. The prevalence of hypercholesterolemia in Yonchon County was substantially lower than that previously suggested, albeit that of hypertriglyceridemia was very high. We could also observe a varying degree of transition in cardiovascular risks related to insulin resistance from the rural to the urban area with rapid emergence of non-communicable diseases as a result of modernization.
本研究旨在确定韩国延川郡高脂血症的患病率，并找出血脂谱对其他心血管危险因素的可能影响。通过对30岁以上注册居民进行随机整群抽样，开展了一项基于人群的横断面研究。在计划调查的3804名受试者中，2520人接受了实际检查。高胆固醇血症（血清胆固醇≥240mg/dl）的患病率仅为1.2%，而高甘油三酯血症（血清甘油三酯≥250mg/dl）的患病率高达11.3%。血清胆固醇、甘油三酯和高密度脂蛋白胆固醇水平与人体测量指标、体重指数和腰臀比相关。糖尿病和/或高血压的患病率随着血清胆固醇或甘油三酯水平的升高而增加。此外，肥胖、糖耐量受损、单纯性高甘油三酯血症和单纯性高胆固醇血症（不合并其他情况）的患病率远低于总体患病率，这表明这些心血管动脉粥样硬化危险因素以多种组合形式存在大量重叠。中心性肥胖被发现是与心血管风险增加相关疾病聚集的一个独立相关因素。延川郡高胆固醇血症的患病率显著低于先前报道的水平，尽管高甘油三酯血症的患病率很高。我们还可以观察到，随着现代化进程中出现的非传染性疾病迅速增加，从农村到城市地区，与胰岛素抵抗相关的心血管风险存在不同程度的转变。
