Fontes B, Poggetti R S
Departamento de Cirurgia, Faculdade de Medicina, Universidade de São Paulo.
Rev Hosp Clin Fac Med Sao Paulo. 1996 Mar-Apr;51(2):72-7.
Multiple organ failure (MOF) is a major cause of death of ICU trauma patients. Despite intensive clinical and experimental investigation, the exact physiopathology of this syndrome is unclear. Although diverse cellular and humoral mediators have been identified, their mechanistic role is still debated. In this article the authors discuss recent results of this investigation. They present recently published criteria for MOF quantification, and focus on the mechanisms and mediators of MOF syndrome, emphasizing the role of sepsis, the intestinal ischemia/reperfusion MOF model, the role of polymorphonuclear neutrophil, and the relationship between adult respiratory distress syndrome (ARDS) and the development of MOF syndrome.
多器官功能衰竭（MOF）是重症监护病房（ICU）创伤患者死亡的主要原因。尽管进行了深入的临床和实验研究，但该综合征的确切病理生理学仍不清楚。虽然已经确定了多种细胞和体液介质，但其作用机制仍存在争议。在本文中，作者讨论了该研究的最新结果。他们介绍了最近发表的MOF量化标准，并重点关注MOF综合征的机制和介质，强调脓毒症的作用、肠道缺血/再灌注MOF模型、多形核中性粒细胞的作用以及成人呼吸窘迫综合征（ARDS）与MOF综合征发展之间的关系。
