Chapel T A, Birmingham D J, Malinowski Y E
Arch Dermatol. 1977 Sep;113(9):1248-9.
An 83-year-old woman had nodular primary localized cutaneous amyloidosis. Several anetodermic, bullous-appearing lesions were observed. Biopsy showed massive amyloid deposition with destruction of elastic and collagen fibers, but no bullous formation. It was concluded that the amyloid deposition induced anetodermic changes creating the clinical appearance of bullae.
一名83岁女性患有结节性原发性局限性皮肤淀粉样变。观察到数个皮肤松弛、呈大疱样外观的损害。活检显示大量淀粉样蛋白沉积，伴弹性纤维和胶原纤维破坏，但无大疱形成。结论是淀粉样蛋白沉积引起皮肤松弛改变，导致大疱的临床表现。
