Hammerschmidt M, Brook A, McMahon A P
Spemann Laboratories, Frieburg, Germany.
Trends Genet. 1997 Jan;13(1):14-21. doi: 10.1016/s0168-9525(96)10051-2.
Members of the Hedgehog family of signaling molecules mediate many important short- and long-range patterning processes during invertebrate and vertebrate development. In the fly, a single hedgehog gene regulates segmental and imaginal disc patterning. In contrast, in vertebrates a hedgehog gene family is involved in the control of left-right asymmetry, polarity in the central nervous system (CNS), somites and limb, organogenesis, chondrogenesis and spermatogenesis. Here, we review recent experiments addressing the function of the various Hedgehog members during invertebrate and vertebrate development.
在无脊椎动物和脊椎动物发育过程中，刺猬信号分子家族的成员介导了许多重要的短程和长程模式形成过程。在果蝇中，单个刺猬基因调节节段和成虫盘模式形成。相比之下，在脊椎动物中，一个刺猬基因家族参与控制左右不对称、中枢神经系统（CNS）的极性、体节和肢体、器官发生、软骨形成和精子发生。在这里，我们综述了最近关于各种刺猬家族成员在无脊椎动物和脊椎动物发育过程中的功能的实验。
