小细胞肺癌中联合及不联合粒细胞集落刺激因子的CODE化疗
CODE chemotherapy with and without granulocyte colony-stimulating factor in small-cell lung cancer.
作者信息
Fukuoka M, Masuda N, Negoro S, Matsui K, Yana T, Kudoh S, Kusunoki Y, Takada M, Kawahara M, Ogawara M, Kodama N, Kubota K, Furuse K
机构信息
Department of Internal Medicine, Osaka Prefectural Habikino Hospital, Japan.
出版信息
Br J Cancer. 1997;75(2):306-9. doi: 10.1038/bjc.1997.50.
Abstract
Sixty-three patients with extensive-stage small-cell lung cancer were randomized to receive either cyclophosphamide, vincristine, doxorubicin and etoposide (CODE) alone or CODE plus recombinant human granulocyte colony-stimulating factor (rhG-CSF). rhG-CSF administration in support of CODE chemotherapy resulted in increased mean total received dose intensity for all drugs (P = 0.03) with a significant improvement in survival (P = 0.004).
摘要
63例广泛期小细胞肺癌患者被随机分为两组，一组单独接受环磷酰胺、长春新碱、阿霉素和依托泊苷（CODE方案）治疗，另一组接受CODE方案加重组人粒细胞集落刺激因子（rhG-CSF）治疗。支持CODE化疗的rhG-CSF给药使所有药物的平均总接受剂量强度增加（P = 0.03），生存率显著提高（P = 0.004）。
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本文引用的文献
1
Recombinant granulocyte colony stimulating factor reduces the infectious complications of cytotoxic chemotherapy.重组粒细胞集落刺激因子可降低细胞毒性化疗的感染并发症。
Eur J Cancer. 1993;29A(3):319-24. doi: 10.1016/0959-8049(93)90376-q.
2
Can cytotoxic dose-intensity be increased by using granulocyte colony-stimulating factor? A randomized controlled trial of lenograstim in small-cell lung cancer.使用粒细胞集落刺激因子能否提高细胞毒性剂量强度？一项关于来格司亭治疗小细胞肺癌的随机对照试验。
J Clin Oncol. 1995 Mar;13(3):652-9. doi: 10.1200/JCO.1995.13.3.652.
3
Dose-intensive chemotherapy in extensive-stage small cell lung cancer.广泛期小细胞肺癌的剂量密集化疗
Semin Oncol. 1994 Feb;21(1 Suppl 1):43-7.
4
Received dose-intensity: a randomized trial of weekly chemotherapy with and without granulocyte colony-stimulating factor in small-cell lung cancer.接受的剂量强度：小细胞肺癌中含与不含粒细胞集落刺激因子的每周化疗随机试验。
J Clin Oncol. 1994 Jan;12(1):77-82. doi: 10.1200/JCO.1994.12.1.77.
5
Dose: a critical factor in cancer chemotherapy.剂量：癌症化疗中的关键因素。
Am J Med. 1980 Oct;69(4):585-94. doi: 10.1016/0002-9343(80)90472-6.
6
7
Phase I/II study of recombinant human granulocyte colony-stimulating factor in patients receiving intensive chemotherapy for small cell lung cancer.重组人粒细胞集落刺激因子用于小细胞肺癌强化化疗患者的Ⅰ/Ⅱ期研究
Br J Cancer. 1987 Dec;56(6):809-13. doi: 10.1038/bjc.1987.295.
8
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9
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J Natl Cancer Inst. 1991 Feb 6;83(3):190-4. doi: 10.1093/jnci/83.3.190.
10
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J Clin Oncol. 1991 Feb;9(2):280-5. doi: 10.1200/JCO.1991.9.2.280.
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