Stoka A M
Instituto Nacional de Diagnóstico e Investigación de la Enfermedad deChagas (INDIECH), Buenos Aires, Argentina.
J Steroid Biochem Mol Biol. 1996 Dec;59(5-6):495-500. doi: 10.1016/s0960-0760(96)00136-7.
The effects of juvenile hormone-III (JH-III) and the juvenile hormone analogues (JHA) methoprene and fenoxycarb on the growth and macromolecular biosynthesis in Trypanosoma cruzi were studied in vitro. It was observed that JH-III and JHA blocked growth and 3H-thymidine incorporation without killing the cells within certain concentrations (< or = 1 x 10(-4) M), but they caused cellular death at concentrations over 1 x 10(-3) M. The inhibitory effect on growth was partially reversible. On the other hand, the inhibitory action of JH-III, methoprene and fenoxycarb was an unspecific effect according to the results obtained with Leishmania mexicana mexicana (promastigotes) and human peripheral blood lymphocytes. The JHA have a good possibility of being used in the control of trypanosomiasis.
在体外研究了保幼激素III（JH-III）以及保幼激素类似物（JHA）烯虫酯和苯氧威对克氏锥虫生长和大分子生物合成的影响。观察到在一定浓度（≤1×10⁻⁴ M）下，JH-III和JHA可阻断生长和³H-胸腺嘧啶核苷掺入，但不会杀死细胞，但在浓度超过1×10⁻³ M时会导致细胞死亡。对生长的抑制作用部分可逆。另一方面，根据墨西哥利什曼原虫（前鞭毛体）和人外周血淋巴细胞的实验结果，JH-III、烯虫酯和苯氧威的抑制作用是非特异性的。JHA很有可能用于控制锥虫病。
