Rodriguez J B, Zhong L, Docampo R, Wimmer Z, Gros E G
Departamento de Química Orgánica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Argentina.
Bioorg Med Chem Lett. 1998 Nov 17;8(22):3257-60. doi: 10.1016/s0960-894x(98)00590-3.
Several compounds, structurally related to the insect growth regulator Fenoxycarb, exhibited interesting inhibition action to control proliferation of Trypanosoma cruzi, the parasite responsible for Chagas' disease. Some of these drugs were shown to be potent growth inhibitors of this parasite. All of these drugs had previously presented juvenoid activity on several non-related bug species such as Tenebrio molitor, Galleria mellonella, Dysdercus cingulatos, and Pyrrhocoris apterus.
几种在结构上与昆虫生长调节剂苯氧威相关的化合物，对控制恰加斯病的病原体克氏锥虫的增殖表现出有趣的抑制作用。其中一些药物被证明是这种寄生虫的有效生长抑制剂。所有这些药物此前在几种无关的昆虫物种上，如黄粉虫、大蜡螟、红蝽和黑腹果蝇，均表现出保幼激素活性。
