幻觉和帕金森症体征有助于在就诊时将患有痴呆和皮质路易体病的患者与阿尔茨海默病患者区分开来：一项临床病理研究。
Hallucinations and signs of parkinsonism help distinguish patients with dementia and cortical Lewy bodies from patients with Alzheimer's disease at presentation: a clinicopathological study.
作者信息
Ala T A, Yang K H, Sung J H, Frey W H
机构信息
Department of Neurology, Ramsey Clinic/Health-Partners, University of Minnesota, St Paul, USA.
出版信息
J Neurol Neurosurg Psychiatry. 1997 Jan;62(1):16-21. doi: 10.1136/jnnp.62.1.16.
Abstract
OBJECTIVES
To compare, in a retrospective clinicopathological study, the presentation features of patients with dementia and cortical Lewy bodies (Lewy body dementia) with those of patients with Alzheimer's disease.
METHODS
From a population of 426 cases from the dementia brain bank, 39 cases of Lewy body dementia and 61 cases of Alzheimer's disease with presentation details were identified.
RESULTS
The Lewy body dementia group had significantly more frequent hallucinations (23% v 3%, P = 0.006) and signs of parkinsonism (41% v 5%, P < 0.0001) than the Alzheimer's disease group. The Lewy body dementia group also had a greater proportion of men (62% v 34%, P = 0.013).
CONCLUSION
Hallucinations and signs of parkinsonism help distinguish Lewy body dementia from Alzheimer's disease at presentation. These indicators may not be very sensitive, because they were reported for less than half of the patients with Lewy body dementia.
摘要
目的
在一项回顾性临床病理研究中，比较痴呆伴皮质路易体（路易体痴呆）患者与阿尔茨海默病患者的临床表现特征。
方法
从痴呆症脑库的426例病例中，确定了39例路易体痴呆患者和61例有临床表现细节的阿尔茨海默病患者。
结果
路易体痴呆组的幻觉（23%对3%，P = 0.006）和帕金森症体征（41%对5%，P < 0.0001）比阿尔茨海默病组更常见。路易体痴呆组男性比例也更高（62%对34%，P = 0.013）。
结论
幻觉和帕金森症体征有助于在发病时将路易体痴呆与阿尔茨海默病区分开来。这些指标可能不太敏感，因为报告有这些症状的路易体痴呆患者不到一半。
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